Contract manufacturing
JAFRAL offers custom contract manufacturing of biomolecules of various volumes, purities and concentrations. We are aware that speed is one of the crucial factors in drug development, so we do our upmost to reduce the time taken to deliver to our clients. The majority of biomolecules are delivered according to following timeline:
We can provide clients with phages of an appropriate purity and at high titers, reducing the amount of material that needs to be handled.
Inquiry
Offer
CDA
Order
2– 4 weeks
Delivery
All material provided by JAFRAL is manufactured using techniques that are scalable, which enables the subsequent production of the large quantities of material needed in the later stages of development.
Excellence, reliability, dedication and vast experience bio-processing make JAFRAL the best partner for manufacturing.
Contract manufacturing
JAFRAL offers custom contract manufacturing of biomolecules of various volumes, purities and concentrations. We are aware that speed is one of the crucial factors in drug development, so we do our upmost to reduce the time taken to deliver to our clients. The majority of biomolecules are delivered according to following timeline:
Inquiry
Offer
CDA
Order
2– 4 weeks
Delivery
We can provide clients with phages of an appropriate purity and at high titers, reducing the amount of material that needs to be handled.
All material provided by JAFRAL is manufactured using techniques that are scalable, which enables the subsequent production of the large quantities of material needed in the later stages of development.
Excellence, reliability, dedication and vast experience bio-processing make JAFRAL the best partner for manufacturing.
Process development and scale up
JAFRAL can develop a complete production process or optimize an existing one. Our experience with different molecules enables us to offer model, developmental, and methodological optimization from petri dish to bioreactor, and from lab scale to pilot scale purification. The complete manufacturing process results in high concentrations, high yields, and high purities, delivered in a cost effective manner using state of the art technology and optimized upstream and downstream processes.
We provide our customers:
Media optimization or transfer to animal component free media
Optimization of your current processes
Easily Scalable and cost efficient upstream and downstream processes that can be trasfered to GMP
Analytical studies to determine all major impurities (proteins, DNA, endotoxins etc)
Analytical methods for monitoring the complete manufacturing process and for batch analysis based upon the latest FDA and EMEA recommendations
Analytics
JAFRAL will provide detailed analytical characterization of biomolecules at each step of development and production using a broad set of methods and analytical procedures.
Detailed results from monitoring of all parameters influencing product can be provided along with a standard Certificate of Analysis, which is provided with each product.
Methods:
Plaque assays
Spectrophotometry (UV/visible)
Fluorimetry
Picogreen assays
LAL test
Agarose electrophoresis
SDS-PAGE
ELISA
PCR
Tangential flow filtration/Diafiltration
Size exclusion HPLC
Ion exchange chromatography
Reverse phase chromatography
Other methods defined by client
Project Management
JAFRAL believes that each project should be managed by single point of contact and this dedicated project manager will provide regular process updates either through electronic media or face-to-face meetings. The project manager will always be up to date with timeline and milestone tracking while monitoring the budget which has been previously agreed with our clients.
Discover The Future
Our preferred approach is to work side by side with our customers from a very early stage